My name is Lars Fruergaard Jorgensen, and I'm the CEO of Novo Nordisk. The effective tax rate in '22 was 19. Smok Novo 2S Mouth Piece. By basics I mean the Novo 2s has no buttons, no adjustable airflow and no changeable coils, you just fill your pod and off you go. The strong sales growth has unfortunately resulted in periodic supply constraints and related job shortages notifications across a number of products and geographies. And then, yes, we continue to scale up manufacturing capacity of Wegovy. If there's a breakout genre on Roblox right now, it's definitely fighting games based on the anime Demon Slayer. Novo 2 not working. And that also means that they will be available to patients if the data supports it in a not-so-distant future and still well within the relevant time period for semaglutide. Is RNA next frontier in drug discovery? Your iPhone or Apple Watch can connect you to emergency services after a severe car crash, even if you're unresponsive2, 3. That's a quite unusual situation to have.
Make sure you pod is inserted fully, or try replacing your pod. However the LEDs primary function is to indicate the battery status. And then, separately kind of coming back to icodec. Crash Detection won't cancel any emergency calls already in progress on your iPhone.
If they reach levels of normal BMI or lose significant amounts of weight, do payers then say, "Well, that's brilliant, you're back to normal, " and come off the drug? If we take shorter data points, in the U. Pending home sales hit 10-month low in October | Reuters. S., we're closer to the 50% mark as a data point. The GLP-1 growth rate is the biggest delta to guide. When we look at the market growth, I can start out with the U. S., MAT-wise, based on the latest monthly data points, the latest data points, or we are around 40%, and that would be the same ex-U. And we have one line on track to be online first half of this year and then another line on track to get online second half this year.
What you're guiding today implies capex close to 25 billion to DKK 30 billion Danish krona in 2025. That's right -- they think these 10 stocks are even better buys. So, we know for a fact that patients have been lined up. Firstly, and this relates to some earlier questions. The increase is driven by launch activities and promotional spend for Rybelsus and Ozempic, as well as market development activities for obesity. Is A.I. Drug Discovery and Biotech Hitting Promised Lands yet in 2023. Backed by an interdisciplinary team of machine learning researchers, engineers, and experimental biologists, as well as strategic scientific advisers and world-class investors, Atomic AI is leading the way in AI-augmented structural biology and transforming the design of RNA-targeted and RNA-based medicines to treat undruggable diseases.
5 years after the Wegovy approval and why not earlier? Going forward, we'll be focused on and committed to delivering solid sales and operating profit growth. So, it's overall 80% access, and that equates to -- the effective access or number of lives is approximately 40 million. If you need to contact emergency services, swipe the Emergency Call slider on the screen of your device. If you still haven't responded, your device makes a call to emergency services at the end of the countdown. The researchers successfully applied AlphaFold to an end-to-end AI-powered drug discovery platform called. The fact that we have now initiated these trials is a testimony to the successful integration and fast progression of the RNA-based research and development in Novo Nordisk. Display: LED Indicator. Issue is obviously that we have no results to share. A. Why is my novo 3 not hitting. may help us unlock the secrets of biotechnology and genomics in new ways. The first one on capex. 450Kupv: Free stuff. And, Karsten, on Wegovy capacity versus what we see in the market now.
It comes from the line of Richard Vosser from JPMorgan. The primary endpoint of the 68-week trial is to confirm superiority of oral semaglutide 25 and 50 milligrams versus oral semaglutide 40 milligram on A1c reduction. My Talent Collective. Either way it like it, although it isn't much different from the original. Could be faster charging. It comes from the line of Simon Baker from Redburn. We're still investing in insulin and think we can drive tremendous value for patients and physicians here, still, 100 years in. So, I'm just wondering how this impacts your expectations for that products over, both provability and commercial potential. Free cash flow was 57.
So, very encouraging indeed. Does this make it a little bit more of an international product compared to a U. S. product, given the convenience at play here? It only really comes up in Q&A. When I started using it again the flavour did take an hour or so to come back, but it sure did come back. We have had some 60-plus patients on notice for one product where it's available. From here, hit the book icon and enter your code into the textbox that appears. And Camilla can maybe talk to the commercial potential of both obviously Type 2 and Type 1 diabetes. 2% in '21, mainly reflecting nonrecurring impacts from acquisitions. Net profit increased by 16% and diluted earnings per share increased by 18% to 24. And next slide, please.
We saw particular strong sales growth in North America, driven by accelerated demand for our GLP-1 treatments for both diabetes and obesity. I know you've talked about pent-up demand, but you and Lilly going to start promoting quite actively to develop the market further. As to a specific number for Q4 in round terms between the two impairments and Forma, around DKK 0. And then, to Lars and Karsten, just if I could try my luck and push you to better understand what is possible and what is not. Hopefully, you can hear me OK. Two separate lines of questioning, please. Duration: 0 minutes. Mike Nedelcovych -- Cowen and Company -- Analyst.
For instance what Atomic A. posits is that RNA is functional and worth pursuing as a method of treatment. This is driven by share gains across geographies. Could you look to increase prices a second time later in the year, given the headroom for price increases?
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