The following doses have been studied in scientific research: BY MOUTH: - For poor blood flow in the legs (chronic venous insufficiency): - Standardized red vine grape extract AS 195 (Antistax, Boehringer Ingelheim 360 mg or 720 mg once daily. Arevalo Villena, M., Diez Perez, J., Ubeda, J. F., Navascues, E., and Briones, A. I. Is red vine leaf a blood thinner safe. Eur Arch 2012;13(3):138-143. Venous insufficiency. However, comprehensive safety studies have not yet been performed, and red vine leaf is not at present recommended for pregnant or nursing women, or individuals with severe liver or kidney disease. Translated from French].
Marguerie, C. and Drouet, M. [Occupational eosinophilic lung in a grape grower: role of sulfites]. After 3 months of treatment, those who also received the red vine leaf extracts showed greater improvements in blood clotting factors and in the dissolution of the fibrin clot, with a more pronounced opening up (recanalization) of veins in the affected area. J 2005;12(6):596-600. The most popular herbal treatment for venous insufficiency is horse chestnut. Evaluation of balneotherapy associated with patient education in patients with advanced chronic venous insufficiency: A randomized controlled trial in the spa resort of La Lechere. Sarrat L. [Therapeutic relief of functional problems of the lower legs by Endotelon, a microangioprotector]. Diabetic retinopathy [Insufficient Evidence]. Red vine leaf tablets. Sandra, D., Radha, M., Harishkumar, M., Yuichi, N., Sayuri, O., and Masugi, M. Downregulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 by grape seed proanthocyanidin extract. Khanna, S., Venojarvi, M., Roy, S., Sharma, N., Trikha, P., Bagchi, D., Bagchi, M., and Sen, C. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Jimenez, J. P., Serrano, J., Tabernero, M., Arranz, S., Diaz-Rubio, M. E., Garcia-Diz, L., Goni, I., and Saura-Calixto, F. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. 2002;132(12):3592-3598. According to those studies, oral intake of red vine leaf extract significantly improved all the above clinical outcomes, namely lower leg volume, calf and ankle circumference, tired/heavy legs, tingling sensation, pain, tension sensation in the legs.
Am J Clin Nutr 2002;75:894-9. In Vivo 2011;25(4):657-662. Patients experiencing symptoms, and those who think they may be at risk of venous disease, are urged to obtain an evaluation by a vein specialist to understand their options for treating the underlying cause of their symptoms.
J Chem 7-25-2007;55(15):5948-5955. Int'l d'Antiologie 1989. Guideline daily amounts are those for a typical adult (men and women). Rosa, C. A., Magnoli, C. E., Fraga, M. E., Dalcero, A. M., and Santana, D. Occurrence of ochratoxin A in wine and grape juice marketed in Rio de Janeiro, Brazil. NRV information for non Boots products is calculated by the manufacturer. Larrosa, M., Tomas-Barberan, F. A., and Espin, J. Advanced - Managing venous disease with red vine leaf extract. Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells. Carpentier PH, Satger B. Fairfield, CT: Primary Source; not dated. Planta Med 2007;73(8):731-741.
Scientific Works of the University of Food Technologies - Plovdiv 2008;55(1):367-372. Clifton, P. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. Food Chemistry 2011;128(2):276-283. OPCs are interesting antioxidant chemicals that appear to have the ability to improve collagen (a type of strengthening tissue found in many parts of the body), reduce capillary leakage, and control inflammation. Metabolism 2009;58(12):1743-1746. Research shows that taking grape seed extract twice daily for 3 months improves some but not all markers of liver damage compared to vitamin C supplementation in people with nonalcoholic fatty liver disease. Be careful not to confuse grape with grapefruit, and other similar sounding medicines. Sivarooban, T., Hettiarachchy, N. S., and Johnson, M. Inhibition of Listeria monocytogenes using nisin with grape seed extract on turkey frankfurters stored at 4 and 10 degrees C. J Food Prot. In contrast, in France, Germany and Italy these natural extracts have been widely researched and used for decades, either as nutritional supplements or even actual medicines and are very popular with women suffering from CVI, water retention and cellulite. 2009;139(9):1818S-1823S. Sen, C. Regulation of inducible adhesion molecule expression in human endothelial cells by grape seed proanthocyanidin extract. Vayalil, P. K., Mittal, A., and Katiyar, S. Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B. Carcinogenesis 2004;25(6):987-995. Why We Don't Sell Red Vine Leaf. J Chem 12-31-2003;51(27):7989-7994. L., Varela, B., Garcia, M. T., Carilla, J., Matito, C., Centelles, J. J., Cascante, M., Sort, X., and Bobet, R. Valorization of grape (Vitis vinifera) byproducts.
In a study involving 30 people with acute deep vein thrombosis, all received usual medical treatment with anticoagulants, and half were also given red grape leaf extracts. 2008;144(1-3):323-328. Be sure to have your blood checked regularly. Nuttall SL, Kendall MJ, Bombardelli E, and et al. We also could not find comprehensive safety data to support its use as a supplement. It is widely available in capsules. In vitro effect of hesperidin on root dentin collagen and de/re-mineralization. Is red vine leaf a blood thinner over the counter. Brain Res 7-3-1989;491(1):15-32. Circulation 2001;103:2792-8.. View abstract. J Chem 7-28-2010;58(14):8365-8374. Stockley, C., Teissedre, P. L., Boban, M., Di, Lorenzo C., and Restani, P. Bioavailability of wine-derived phenolic compounds in humans: a review. Cancer Res 6-1-2006;66(11):5960-5967. In venous insufficiency: a double-blind study [translated from Italian].
Changes in calf circumference also decreased and improvements in swelling were at least equivalent to those expected from wearing compression stockings. New York, NY: William Morrow and Co., 1999. Shirataki, Y., Kawase, M., Saito, S., Kurihara, T., Tanaka, W., Satoh, K., Sakagami, H., and Motohashi, N. Selective cytotoxic activity of grape peel and seed extracts against oral tumor cell lines. Pickering, G. J., Karthik, A., Inglis, D., Sears, M., and Ker, K. Detection thresholds for 2-isopropyl-3-methoxypyrazine in Concord and Niagara grape juice.
Sano, A., Yamakoshi, J., Tokutake, S., Tobe, K., Kubota, Y., and Kikuchi, M. Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract. The results also showed a significant dose-related improvement in the treated groups in symptoms such as subjective heaviness, discomfort, and edema. Sensation of tired and heavy legs. Barthomeuf, C., Lamy, S., Blanchette, M., Boivin, D., Gingras, D., and Beliveau, R. Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. Identification and quantification of impact aroma compounds in 4 nonfloral Vitis vinifera varieties grapes. All of them appear to work by strengthening the walls of veins and other vessels, with the net effect of reducing fluid leakage. Rehn D, Golden G, Nocker W, et al. Krešic, G., Dragovic-Uzelac, V., Saftic, M., and Blazevic, N. Cereal bakery products enriched with bioflavonoids - new possibilities of functional food. Advantages of the new micronized form. Pinelo, M., Rubilar, M., Sineiro, J., and Nunez, M. A thermal treatment to increase the antioxidant capacity of natural phenols: catechin, resveratrol and grape extract cases.
Chronic venous insufficiency (CVI) is common in women, especially in older and/or overweight women. Cabernet Sauvignon). Tyagi, A., Agarwal, R., and Agarwal, C. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. The same is true for topical.
Kaur, M., Agarwal, R., and Agarwal, C. Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation. Although there is no direct evidence on its use for varicose veins, bromelain has anti-edema effects similar to treatments used for varicose veins, suggesting that it might be helpful. Early research shows that drinking Concord grape juice daily for 12 weeks can improve verbal learning, but does not improve memory, in older people with age-related mental decline. Kiesewetter H, Koscielny J, Kalus U, et al. Petruzzellis V, Troccoli T, Candiani C, et al.