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Received: Revised: Accepted: Published: DOI: Estimation of tumour regression and growth rates during treatment in patients with advanced prostate cancer: a retrospective analysis. Tumor dynamic model-based decision support for Phase Ib/II combination studies: a retrospective assessment based on resampling of the Phase III study IMpower150. Food and Drug Administration. Maitland ML, Wilkerson J, Karovic S, Zhao B, Flynn J, Zhou M, et al. This perspective paper presents recent developments and future directions to enable wider and robust use of model-based decision frameworks based on pharmacological endpoints. Longitudinal tumor size and neutrophil-to-lymphocyte ratio are prognostic biomarkers for overall survival in patients with advanced non-small cell lung cancer treated with durvalumab. A tumor growth inhibition model based on M-protein levels in subjects with relapsed/refractory multiple myeloma following single-agent carfilzomib use. Early modeled longitudinal CA-125 kinetics and survival of ovarian cancer patients: a GINECO AGO MRC CTU study. A pan-indication machine learning (ML) model for tumor growth inhibition—overall survival (TGI-OS) prediction. Beumer JH, Chu E, Salamone SJ. J Clin Oncol Precision Oncol.
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