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Data Availability Statement. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Umar, S. ; Sarkar, S. ; Cowey, S. ; Singh, P. Activation of NF-κB Is Required for Mediating Proliferative and Antiapoptotic Effects of Progastrin on Proximal Colonic Crypts of Mice, In Vivo. Concept and principles of development. Parzonko, A. ; Makarewicz-Wujec, M. ; Jaszewska, E. ; Harasym., J. ; Kozłowska-Wojciechowska, M. Pro-apoptotic properties of (1, 3)(1, 4)-β-D-glucan from Avena sativa on human melanoma HTB-140 cells in vitro. Materials and Methods. Statistical Analysis.

Concept Development Practice Page 3.1.3

Immunity 2019, 51, 27–41. Cells 2022, 11, 502. Wu, G. S. TRAIL as a Target in Anti-Cancer Therapy. Nam, S. Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (). Bakshi, H. ; Quinn, G. ; Nasef, M. ; Mishra, V. ; Aljabali, A. ; El-Tanani, M. ; Serrano-Aroca, Á. ; Webba Da Silva, M. ; McCarron, P. ; Tambuwala, M. New concept chapter 3. Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-κB/VEGF Pathways. Disclaimer/Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). Informed Consent Statement. Kim, Ji Hyeon, Jeonghyeon Seo, Huiwon No, Takao Kuge, Takahiro Mori, Hisashi Kimoto, and Jin-Kyung Kim.

Cancer 2014, 136, 493–502. Nutrients 2021, 13, 242. Measurement of Apoptotic Cells. Google Scholar] [CrossRef]. Concept development practice page 3.1.3. Anticancer Agents Med. "Low-Molecular-Weight β-1, 3-1, 6-Glucan Derived from Aureobasidium pullulans Exhibits Anticancer Activity by Inducing Apoptosis in Colorectal Cancer Cells" Biomedicines 11, no. LMW-AP-FBG Induces Apoptosis in CT-26 Cells. Cardioprotective Effects of Constitutively Active MEK1 Against H2O2-induced Apoptosis and Autophagy in Cardiomyocytes via The ERK1/2 Signaling Pathway. MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

What Is A Concept Development

Kimura, Y. ; Sumiyoshi, M. ; Suzuki, T. ; Sakanaka, M. Antitumor and Antimetastatic Activity of a Novel Water-Soluble Low Molecular Weight Beta-1, 3-D-Glucan (Branch Beta-1, 6) Isolated from Aureobasidium pullulans 1A1 Strain Black Yeast. © 2023 by the authors. Zhang, S. ; Liu, Y. ; Xiang, D. ; Yang, J. ; Liu, D. ; Ren, X. ; Zhang, C. Assessment of Dose-Response Relationship of 5-Fluorouracil to Murine Intestinal Injury. Kim JH, Seo J, No H, Kuge T, Mori T, Kimoto H, Kim J-K. Biomedicines. Kim, D. ; Min, K. ; Lee, S. Cell Cycle Dysregulation Is Associated with 5-Fluorouracil Resistance in Gastric Cancer Cells. Oana, C. ; Adriana, T. ; Mircea, C. ; Dragos, S. ; Monica, H. Natural Macromolecules with Protective and Antitumor Activity. Determination of Mitochondrial Membrane Potential. Oncogene 2008, 27, 5599–5611. Biomedicines 2023, 11, 529. Fantini, M. C. ; Guadagni, I. Multi-Caspase Assay. 2020, 40, 3247–3254. Western Blot Analysis.

Mata-Martínez, P. ; Bergón-Gutiérrez, M. ; Del Fresno, C. Dectin-1 Signaling Update: New Perspectives for Trained Immunity. Chao, T. ; Chang, G. ; Chen, W. Y. ; Chen, P. ; Mao, F. The Synergistic Effect of Rapamycin Combined with 5-Fluorouracil in BALB/c Mice Bearing CT-26 Tumor Cells. Sun, X. ; Ng, T. ; Sham, K. ; Zhang, L. ; Chan, M. V. ; Wu, W. ; Cheng, C. Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer. Azwar, S. ; Seow, H. F. ; Abdullah, M. ; Faisal Jabar, M. ; Mohtarrudin, N. Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer Treatment. Author Contributions.

New Concept Chapter 3

From Inflammation to Colitis-Associated Colorectal Cancer in Inflammatory Bowel Disease: Pathogenesis and Impact of Current Therapies. Tsujimoto, Y. ; Shimizu, S. Bcl-2 Family: Life-or-Death Switch. Licensee MDPI, Basel, Switzerland. Kawata, K. ; Iwai, A. ; Muramatsu, D. ; Aoki, S. ; Uchiyama, H. ; Okabe, M. ; Hayakawa, S. ; Takaoka, A. ; Miyazaki, T. Stimulation of macrophages with the β-glucan produced by Aureobasidium pullulans promotes the secretion of tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Gupta, S. ; Prasad, S. ; Sethumadhavan, D. ; Nair, M. ; Mo, Y. ; Aggarwal, B. PLoS ONE 2015, 10, e0124809. Tada, R. ; Tanioka, A. ; Iwasawa, H. ; Hatashima, K. ; Shoji, Y. ; Ishibashi, K. ; Adachi, Y. ; Yamazaki, M. Structural Characterization and Biological Activities of a Unique Type β-D-Glucan Obtained from Aureobasidium pullulans. LMW-AP-FBG Reduces Growth of Syngeneic Transplanted CT-26 Tumors in Mice. Cells and Cell Viability Assay.

Biology 2021, 10, 854. Conflicts of Interest. Weng, W. ; Feng, J. ; Qin, H. ; Ma, Y. Molecular Therapy of Colorectal Cancer: Progress and Future Directions. Sun, M. ; Chen, X. ; Han, M. ; Yang, Y. N. ; Gao, X. ; Ma, X. ; Huang, Y. ; Li, X. ; Gai, M. T. ; Liu, F. ; et al. 2006, 26, 4131–4141. No, H. W. ; Kim, J. ; Seo, C. R. ; Lee, D. E. H. ; Mori, T. ; Kimoto, H. K. Anti-Inflammatory Effects of β-1, 3-1, 6-Glucan Derived from Black Yeast Aureobasidium pullulans in RAW264.

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2011, 404, 1105–1110. Schiavone, M. ; Vax, A. ; Formosa, C. ; Martin-Yken, H. ; Dague, E. ; François, J. M. A Combined Chemical and Enzymatic Method to Determine Quantitatively The Polysaccharide Components in The Cell Wall of Yeasts. Jin, H. ; Li, M. ; Tian, F. ; Yu, F. ; Zhao, W. An Overview of Antitumour Activity of Polysaccharides. Institutional Review Board Statement. Remya, R. ; Rajasree, S. ; Suman, T. ; Aranganathan, L. ; Gayathri, S. ; Gobalakrishnan, M. ; Karthih, M. Laminarin based AgNPs using brown seaweed Turbinaria ornata and its induction of apoptosis in human retinoblastoma Y79 cancer cell lines. Yoshikawa, M. ; Ikeda, F. ; Kato, Y. ; Kuge., T. Induction of IFN-γ by a highly branched 1, 3-β-d-glucan from Aureobasidium pullulans in mouse-derived splenocytes via dectin-1-independent pathways. Todoric, J. ; Antonucci, L. ; Karin, M. Targeting Inflammation in Cancer Prevention and Therapy. Gene 2020, 726, 144132. LMW-AP-FBG Reduces Mitochondrial Membrane Potential in CT-26 Cells.

Nikolic, I. ; Kastratovic, T. ; Zelen, I. ; Zivanovic, A. ; Arsenijevic, S. ; Mitrovic., M. Cytosolic Pro-Apoptotic SPIKE Induces Mitochondrial Apoptosis in Cancer. Shamas-Din, A. ; Kale, J. ; Leber, B. ; Andrews, D. Mechanisms of Action of Bcl-2 Family Proteins. Tsoni, S. ; Brown, G. D. Beta-Glucans and dectin-1. Hayashi, N. ; Shoubayashi, Y. ; Fukudome, K. Hydrothermal processing of β-glucan from Aureobasidium pullulans produces a low molecular weight reagent that regulates inflammatory responses induced by TLR ligands. Greten, F. ; Grivennikov, S. I. Inflammation and Cancer: Triggers, Mechanisms, and Consequences. 2013, 19, 4465–4476. B. Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing The Proinflammatory Microenvironment. Tanioka, A. ; Tanabe, K. ; Hosono, A. ; Kawakami, H. ; Kaminogawa, S. ; Tsubaki, K. ; Hachimura, S. Enhancement of Intestinal Immune Function in Mice by β-D-Glucan from Aureobasidium pullulans ADK-34.

Concept And Principles Of Development

Vaideeswar, P. ; Kundu, S. ; Singaravel, S. ; Tyagi, S. Spontaneous Aortic Rupture: Report of Two Cases with Review of Literature. LMW-AP-FBG Reduces Viability of CT-26 Colon Cancer Cells. Molecules 2022, 27, 8083. 2014, 34, 3329–3335.

Soleimani, A. ; Rahmani, F. ; Ferns, G. ; Ryzhikov, M. ; Avan, A. ; Hassanian, S. Role of The NF-κB Signaling Pathway in The Pathogenesis of Colorectal Cancer. Bray, F. ; Ferlay, J. ; Soerjomataram, I. ; Siegel, R. L. ; Torre, L. A. ; Jemal, A. Google Scholar] [CrossRef][Green Version]. Goodridge, H. ; Wolf, A. ; Underhill, D. Beta-glucan recognition by the innate immune system. Suzuki, T. ; Kusano, K. ; Kondo, N. ; Nishikawa, K. ; Kuge, T. ; Ohno, N. Biological Activity of High-Purity β-1, 3-1, 6-Glucan Derived from The Black Yeast Aureobasidium pullulans: A Literature Review.